Organ effects of cholinergic agonists e Eyes:contraction of ciliary muscle and smooth muscle of the iris sphincter(miosis)-aqueous humor outflow, drainage of the anterior chamber e Cardiovascular:Bradycardia(possibly preceded by tachycardia),vasodilation (all vascular beds including pulmonary and coronary-M3)and hypotension, reduction of the contraction strength(atrial and ventricular cells,Ik+Icadiastolic depolarization,1NO- inhibitable ATP),negative chronotropic effect (inhibition of adrenergic activation). Respiratory:Bronchoconstriction,mucus secretionOrgan effects of cholinergic agonists • Eyes: contraction of ciliary muscle and smooth muscle of the iris sphincter (miosis) – aqueous humor outflow, drainage of the anterior chamber • Cardiovascular: Bradycardia (possibly preceded by tachycardia), vasodilation (all vascular beds including pulmonary and coronary – M3) and hypotension, reduction of the contraction strength (atrial and ventricular cells, IK+ , ICa2+ diastolic depolarization , NO￾inhibitable ATP), negative chronotropic effect (inhibition of adrenergic activation). • Respiratory: Bronchoconstriction, mucus secretion