Chapter 14 Signal-Transduction Pathways 2 6 Ras is a member of this family of proteins. Ans:I Section:14.3 7 A gene that leads to the transformation of susceptible cell types into cell types with cancerlike characteristics. Ans:k Section:14.5 8 This protein binds to calcium ions and serves as a Ca2+sensor in eukaryotic cells. Ans:b Section:14.1 9 This molecule is considered as a secondary messenger. Ans:g Section:Introduction 10 This enzyme catalyzes the cleavage of PIP2. Ans:h Section:14.1 Fill in the Blank Questions 1 Protein kinase A phosphorylates serine and residues. Ans:threonine Section:14.1 2 is the membrane protein that catalyzes the conversion of ATP to cAMP. Ans:Adenylate cyclase Section:14,1 3 The cytosolic side,or B subunit,of the insulin receptor is a kinase. Ans:tyrosine Section:14.2 4 The receptor is approximately 50%identical in amino acid sequence with the EGF receptor and has similar domain structure,but it does not bind any known ligand. Ans:Her2 Section:14.3 is a secondary messenger and is abbreviated IP3. Ans:Inositol 1,4,5-trisphosphate Section:Introduction 6 7TM is an abbreviation for receptors. Ans:seven-transmembrane-helix Section:14.1Chapter 14 Signal-Transduction Pathways 2 6 ____________ Ras is a member of this family of proteins. Ans: l Section: 14.3 7 ____________ A gene that leads to the transformation of susceptible cell types into cell types with cancerlike characteristics. Ans: k Section: 14.5 8 ____________ This protein binds to calcium ions and serves as a Ca 2+ sensor in eukaryotic cells. Ans: b Section: 14.1 9 ____________ This molecule is considered as a secondary messenger. Ans: g Section: Introduction 10 ____________ This enzyme catalyzes the cleavage of PIP2. Ans: h Section: 14.1 Fill in the Blank Questions 1 Protein kinase A phosphorylates serine and ___________ residues. Ans: threonine Section: 14.1 2 ____________ is the membrane protein that catalyzes the conversion of ATP to cAMP. Ans: Adenylate cyclase Section: 14,1 3 The cytosolic side, or β subunit, of the insulin receptor is a ________________ kinase. Ans: tyrosine Section: 14.2 4 The ________ receptor is approximately 50% identical in amino acid sequence with the EGF receptor and has similar domain structure, but it does not bind any known ligand. Ans: Her2 Section: 14.3 5 _______________________ is a secondary messenger and is abbreviated IP3. Ans: Inositol 1, 4, 5-trisphosphate Section: Introduction 6 7TM is an abbreviation for _______________________ receptors. Ans: seven-transmembrane-helix Section: 14.1