Contents lists available at Science Direct B Biochemical and Biophysical Research Communications B EI SEVIER journalhomepagewww.elsevier.com/locate/ybbre Mitochondrial dysfunction induced by knockdown of mortalin is rescued by Parkin Hui Yang. 1, Xiaoping Zhou. 1, Xiaoyu Liu Ling Yang, Qiang Chen Dongliang Zhao, Ji Zuo, Wen Lit Deparment of Celluar and Gentic Medrine, Shanghai Medcal Collge Furlan Universy, Shangha 200032. FR ine DEpartment of Neurolog. Agitated Prop Hospital Jiang Universiry, Zhenjiang 2120m. jiangsu Province. PR China ARTICLE INFO A BSTRACT Ande history Mutations in the parkin gene are the most common cause of autosomal recessive Parkinsons disease(PD). Received 7 May 2011 As an B3-ubiquitin ligase. Parkin is assodated with mitochondnal dynamics and mitophagy. Mortalin, a Available online 26 May 2011 olecular chaperone, is located primarily in mitochondria, where it functions to maintain mitochondnal