Research Mitochondrial dysfunction induced by knockdown of mortalin is rescued by parkin Animal Models: neurotoxin 6-hydroxydopamine, also known as 6 OHDA, creates a model of Parkinson's disease in rats by targeting and destroying dopaminergic neurons in the nigrostriatal pathway when injected into the substantia nigra Neuroprotective treatments: a vaccine that primes the human immune system to destroy alpha-synuclein, PDola(developed by Austrian company, Affiris), has entered clinical trials in humansResearch • Mitochondrial dysfunction induced by knockdown of mortalin is rescued by Parkin • Animal Models: neurotoxin 6-hydroxydopamine, also known as 6- OHDA, creates a model of Parkinson’s disease in rats by targeting and destroying dopaminergic neurons in the nigrostriatal pathway when injected into the substantia nigra • Neuroprotective treatments: A vaccine that primes the human immune system to destroy alpha-synuclein, PD01A (developed by Austrian company, Affiris), has entered clinical trials in humans