With respect to agents to be used in the animal la boratory factors for consideration include 1. The normal route of transmission 2. The volumes and concentrations to be used 3. The route of inoculation 4. Whether and by what route these agents may be excreted排泄With respect to agents to be used in the animal laboratory, factors for consideration include: 1. The normal route of transmission 2. The volumes and concentrations to be used 3. The route of inoculation 4. Whether and by what route these agents may be excreted排泄