General properties of Macrolides 3. Antimicrobial spectrum: G+ organisms: cocci: streptococcus pyogenes, hemolytic streptococcus and streptococcus pneumoniae(化脓性、溶血性和肺炎链球菌), staphylococcus( produceβ lactamase or MRSA耐甲氧西林的金葡菌) bacilli: Corynebacterium diphtheria(白喉杆菌), bacillus anthraci(炭疽杆菌), clostridium tetani(破伤风杆菌) G-organisms CoCCI: meningococcus(脑膜炎奈瑟菌),N. gonorrhoeae(淋病奈瑟菌 - bacilli: legionella pneumophila(军团菌), bordetella pertussis(百日咳杆菌) haemophilus influenzae(流感嗜血杆菌)(对大肠埃希菌、变形杆菌无效) Other: - anaerobe(厌氧菌) mycoplasma pneumoniae(肺炎支原体) chlamydia(衣原体) rickettsia(立克次体) spirochetes(螺旋体)3. Antimicrobial spectrum： G+ organisms: - cocci: streptococcus pyogenes, hemolytic streptococcus and streptococcus pneumoniae (化脓性、溶血性和肺炎链球菌), staphylococcus (produce β- lactamase or MRSA耐甲氧西林的金葡菌) - bacilli: Corynebacterium diphtheria (白喉杆菌), bacillus anthraci (炭疽杆菌) ， clostridium tetani (破伤风杆菌) G- organisms: - cocci: meningococcus (脑膜炎奈瑟菌)， N. gonorrhoeae (淋病奈瑟菌) - bacilli:legionella pneumophila (军团菌), bordertella pertussis(百日咳杆菌), haemophilus influenzae (流感嗜血杆菌)（对大肠埃希菌、变形杆菌无效） Other： - anaerobe （厌氧菌） - mycoplasma pneumoniae （肺炎支原体） - chlamydia （衣原体） - rickettsia （立克次体） - spirochetes （螺旋体） General properties of Macrolides