General properties of Macrolides 4. Mechanism of action(bind to P site) 1. Blocking translocation of peptidyl tRNA from A site to P site (B 位,14) 2 Preventing the peptidyl transfer(转肽,16C) 3. Inhibiting the formation of functional 70s ribosome 4. Bind to L27 and L22 protein to cause dissociation of peptidyl tRNA from the ribosome4. Mechanism of action (bind to P site): General properties of Macrolides 1. Blocking translocation of peptidyl tRNAfrom A site to P site (移 位, 14) 2. Preventing the peptidyl transfer (转肽, 16C) 3. Inhibiting the formation of functional 70s ribosome 4. Bind to L27 and L22 protein to cause dissociation of peptidyl￾tRNA from the ribosome