General properties of macrolides 5 ADME of Macrolides. (Absorption Erythromycin is destroyed by stomach acid and must be administrated with enteric coating Stearates(硬脂酸) and ester(酯化) are fairly acid- resistant and somewhat better absorbed Clarithromycin and azithromycin are stable to acid Food interferes with absorption(except Clarithromycin)5. ADME of Macrolides: (1)Absorption: • Erythromycin is destroyed by stomach acid and must be administrated with enteric coating. • Stearates (硬脂酸) and ester (酯化) are fairly acid￾resistant and somewhat better absorbed. • Clarithromycin and Azithromycin are stable to acid. • Food interferes with absorption (except Clarithromycin). General properties of macrolides