General properties of macrolides 5. ADME of macrolides (2 Distribution: Erythromycin diffuses readily into most tissues, including prostatic fluid and placenta, BBB impenetrable. (3)Metabolism and Elimination: most metabolized in the liver. excreted in the bile clarithromycin and its metabolite excreted in urine5. ADME of macrolides: (2)Distribution: Erythromycin diffuses readily into most tissues, including prostatic fluid and placenta, BBB impenetrable. (3) Metabolism and Elimination: most metabolized in the liver, excreted in the bile； clarithromycin and its metabolite excreted in urine. General properties of macrolides