Cutaneous Intestina Pulmonary Low-level germination and Low-level germination at growth at one site lead to local one site leads to massive edema and necrotic lesion effusion mucosal edema, and necrotic lesion .Endospores are phagocytosed by Q macrophages and pore germinate Macrophya Bacillus Macrophages containing bacilli Bacterial virulence factors Capsule detach and Exotoxins migrate to the Other factors g nal lymph Regional lymph node node•Endospores are phagocytosed by macrophages and germinate •Macrophages containing bacilli detach and migrate to the regional lymph node