ANTHRAX TOXINS PA 20 kDa PA EF Host Protease The complex(pa+LF or PAtEF is internalized by endocytosis PA acidification of the endosome HOST CELL LF the lf or ef cross the membrane into the cytosol via PA-mediated ion-conductive channelsANTHRAX TOXINS LF EF PA PA PA LF Host Protease HOST CELL 20 kDa The complex (PA+LF or PA+EF) is internalized by endocytosis acidification of the endosome the LF or EF cross the membrane into the cytosol via PA-mediated ion-conductive channels