1AA%: PROTEIN TYROS INE PHOSP HATASE 1B(321)w MEMEKEFEQIDKSGSWAAIYQDIRHEASDE PCRVAKLP KNKNRNRYRDVSPFDHSRIKI QED NDYINASL IKMEEAQRSYIL TQGPLPNTCGHEWEMVWEQKSRGVVMLNRYMEKGSI CAQYUP QKEEKEMIFEDTNLKLTLISED IKSYYTVROLELENLTTQETRE ILHEHYTTU DEGVPESPASELNFLEKYRESGSLSPEHGPVYYHSSAGIGRSGTE CLADTCLL LMDKRE PSSVDIKKVLL EMRKF RMGLIQTAD OLRESYLAVIEGAKF IMG DS SYQDQWKELS HEDI PP GHIPPPPRPP KRIlEPHN+ (a) 1 MEMEKEFEQI DKSGSWAAIY QDIRHEASDF PCRVAKLPKN KNRNRYRDVS HHHHHHHH HHHT THHHHH HHHHHH TTTTTGGG GGG S TT 51 PFDHSRIKLH QEDNDYINAS LIKMEEAQRS YIL TQGPLPN TCGHF WEMVW TTTB B S SS B SEE EEEETTTTEE EEEE TT THHHHHHHHH 101 EQKSRGVVML NRVMEKGSLK CAQYUPQKEE KEMIFED TNL KL TL ISEDIK HTT EEEE S SEETTEE SS SSTT S EEETTTTE EEEEEEEE 151 SYYTVRQLEL ENLTTQE TRE ILHFHYTTWP DF GVPESPAS FLNFLFKVRE SSEEEEEEEE EETTTTEEEE EEEEEE TT S HHH HHHHHHHHHH 201 SGSLSPEHGP VVVHSSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL TTTTTTTS EEEE SSSSS HHHHHHHHHH HHHHHHHHT GGG HHHHH 251 LEMRKFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKEL SHEDLE HHHHTTTTT S SHHHHHHH HHHHHHHHHH HTTTTHHHHH HHHHHT 301 PPPGHIPPPP RPPKRILEPH N H=helix, B=residue in isolated beta bridge, E=extended beta strand; G=310 helix I=pi helix, T-hydrogen bonded turn, S=bende (b) (c) 图7.1酪氨酸磷酸酶的序列及结构:(a)氨基酸序列;(b)二級结构;(c) 空结构