Autophagy Regulation Highly conserved and regulated process that maintains cellular homeostasis and protects cells against starvation and microbe invasion Birth wth Factor ental Interruption) riation Decreased Black in Extracellular Nutrients Nutrient Uptake creased intracellular Nutrients Mitochondria Nutrent Sensors TCAcvcle s Soning Events Protein Synthesis Falty Acids Autophagy Amino Acids Pre- Autophagosome Degradation of Structure cytoplasma Isolation Components Membrane Autophagosome Autolysosome Figure 1. Mammalian Autophagy in Cellular Defense against Two Forms of Nutrient Stress: Birth and Growth Factor DeprivationAutophagy Regulation ◼ Highly conserved and regulated process that maintains cellular homeostasis and protects cells against starvation and microbe invasion