Autophagy: Function The principal role of autophagy this ubiquitous eukaryotic homeostatic mechanism is to ensure cell survival under adverse conditions nutrient absence growth factor withdrawal accumulation of toxic protein aggregates Faulty organelles(e.g leaky mitochondria) infection by intracellularAutophagy: Function ◼ The principal role of Autophagy this ubiquitous eukaryotic homeostatic mechanism is to ensure cell survival under adverse conditions ◼ nutrient absence, ◼ growth factor withdrawal ◼ accumulation of toxic protein aggregates ◼ Faulty organelles (e.g., leaky mitochondria) ◼ infection by intracellular