point) 6 Can base-pair with the 3-end of the 16S rRNA (0.5 point) 5. Alternative splicing ①可变剪接_(05 point.) 2 The generation of different mature mRNAs from a particular type of gene transcript by choosing different 5-and 3-splice sites(2 point) 6. Ribozyme ①核酶_(O5 point.) 2 an RNa molecule capable of catalyzing a chemical reaction(2 point) 7. p-dependent termination ①p-依赖型转录终止_(0.5 point.) 2 During bacterial transcription, some terminator sites do not form strong hairpins thus termination of the transcription by bacterial rNa polymerase requires the assistance of an accessory factor called rho(p) protein(2 point) 8. RNA editing ①RNA编辑(O5mmnt 2 A form of RNa processing in which nucleotide sequence of the primary transcript is altered by either changing, inserting or deleting residues at the spec ific points along the molecule(2 point) 9. DNA lesions ①DNA损伤_(O5p0in) 2 An alteration to the normal chemical or physical structure of the DNA(2 point) The lesions can lead to cell death or DNA mutation(1 point) 10. Protein targeting ①蛋白定位(O5mmnt 2 Synthesis of eukaryotic proteins is usually occurred in cytoplasm(0.5 point) 3 However, many proteins need to be transported to specific cellular locations, such as nucleus, mitochondrion or chloroplast, to exert their biological functions. This process is called protein targeting (1 point) 4 The ultimate cellular location of proteins is often determined by specific, relative short, amino acid sequences within the proteins themselves. The sequence inside of a protein determining the cellular location of the protein is called signal sequence(I point) PART IL: MULTIPLE CHOICES (I points each) Select the one best answer for each question 1. The catalytic activity for peptide bond formation(the peptidyl transferase activity)is located in the 1) RNA of the large ribosomal subunit. 2) leader sequence of the messenger RNA 3) RNA of the small ribosomal subunit 4) proteins of the small ribosomal subunit 5) proteins of the large ribosomal subunit 2. Bid irectional and semi-conservative are two terms that refer to transcriptipoint) ⑤ Can base-pair with the 3’-end of the 16S rRNA (0.5 point) 5. Alternative splicing ① 可变剪接 （0.5 point） ② The generation of different mature mRNAs from a particular type of gene transcript by choosing different 5’- and 3’-splice sites (2 point). 6. Ribozyme ① 核酶 （0.5 point） ② an RNA molecule capable of catalyzing a chemical reaction (2 point). 7. -dependent termination ① -依赖型转录终止 （0.5 point） ② During bacterial transcription, some terminator sites do not form strong hairpins, thus termination of the transcription by bacterial RNA polymerase requires the assistance of an accessory factor called rho () protein (2 point). 8. RNA editing ① RNA 编辑 （0.5 point） ② A form of RNA processing in which nucleotide sequence of the primary transcript is altered by either changing, inserting or deleting residues at the specific points along the molecule (2 point). 9. DNA lesions ① DNA 损伤 （0.5 point） ② An alteration to the normal chemical or physical structure of the DNA (2 point). ③ The lesions can lead to cell death or DNA mutation (1 point). 10. Protein targeting ① 蛋白定位 （0.5 point） ② Synthesis of eukaryotic proteins is usually occurred in cytoplasm (0.5 point). ③ However, many proteins need to be transported to specific cellular locations, such as nucleus, mitochondrion or chloroplast, to exert their biological functions. This process is called protein targeting (1 point). ④ The ultimate cellular location of proteins is often determined by specific, relative short, amino acid sequences within the proteins themselves. The sequence inside of a protein determining the cellular location of the protein is called signal sequence (1 point). PART II: MULTIPLE CHOICES (1 points each) Select the one best answer for each question. 1. The catalytic activity for peptide bond formation (the peptidyl transferase activity) is located in the: 1) RNA of the large ribosomal subunit. 2) leader sequence of the messenger RNA. 3) RNA of the small ribosomal subunit. 4) proteins of the small ribosomal subunit. 5) proteins of the large ribosomal subunit. 2. Bidirectional and semi-conservative are two terms that refer to: 1) transcription