Stroma 1. Fibroblasts in tumor Activated fibroblast GF GFR activated 2. Genetic alteration Juvenile polyposis syndrome (JPS), Cowen syndromeetc Dominant hereditary Stromal cells abnormality, Hamartoma High risk for colon cancer PTEN and others Landscaper Stroma abnormal microenviroment “ Microenviroment of tumor- host interface” 2YY制作 12ZYY制作 12 Stroma: 1. Fibroblasts in tumor: “Activated fibroblast” GF GF R activated 2. Genetic alteration: Juvenile polyposis syndrome (JPS), Cowen syndrome etc Dominant hereditary Stromal cells abnormality, Hamartoma High risk for colon cancer PTEN and others “Landscaper” “Stroma abnormal microenviroment” “Microenviroment of tumor-host interface