安徽医科大学国际教育学院教案与讲稿 ●Eclampsia agents Drugs commonly used by women of childbearing potential ●Antidepressants ●Asthma drugs 【Teratogenesis】 5min General Principles of Teratology Teratogens act with specificity ● Teratogens demonstrate a dose-response relationship Teratogens must reach the conceptus Effects depend on the development stage when exposed Genotype of mother and fetus effect susceptibility Placental Transfer of Drugs 【Drug Therapy in Nursing Mother】 5min ●Drugs in breast milk Evaluation of drugs in breast milk Factors Effecting the Milk /Plasma Concentration Ratio 【General Recommendations】 3 min Drugs considered safe for pregnancy are usually safe during lactation ● Decrease the drug dose to the infant by feeding just prior to drug administration Infant blood levels can be monitored and should be less than therapeutic dosage 3安徽医科大学国际教育学院教案与讲稿 3 Eclampsia agents Drugs commonly used by women of childbearing potential Antidepressants Asthma drugs 【Teratogenesis】 5 min General Principles of Teratology Teratogens act with specificity Teratogens demonstrate a dose-response relationship Teratogens must reach the conceptus Effects depend on the development stage when exposed Genotype of mother and fetus effect susceptibility Placental Transfer of Drugs 【Drug Therapy in Nursing Mother】 5 min Drugs in breast milk Evaluation of drugs in breast milk Factors Effecting the Milk / Plasma Concentration Ratio 【General Recommendations】 3 min Drugs considered safe for pregnancy are usually safe during lactation Decrease the drug dose to the infant by feeding just prior to drug administration Infant blood levels can be monitored and should be less than therapeutic dosage