安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Drug therapy in pregant and nursing women Chapter:22 Teacher's name: Chang Yan Grade:2013 Department:Clinical Medicine,School of International Education Time:14:30-16:50 Date(D/M/Y):3/30/2016 Lecture Notes: 【Raise a question】 1min What are special populations? 【Show date】 1min WHO survey showed that 89%of women take prescription drugs during pregnancy (avg=3 prescription each)not including OTC preparation and alternative therapies 【Physiologial Changes in Pregnancy】 8min Gastrointestinal changes Cardiovascular system changes Decrease in albumin concentration Enzymatic activity changes Increase in glomerular filtration rate(GFR) Give examples:Phenytoin Maternal Physiologic Changes Altering PK of Drugs 10 min ●Volume Expansion Protein binding-increase in free fraction of drugs bound to albumin ●Clearance changes Gastrointestinal changes Give examples:Caffeine;Theophylline;Methadone;Ampicllin 【Drug Studies for Pregnancy】 6min Pregnancy Specific Drugs ●Tocolytic agents ●Oxytocic agents 2安徽医科大学国际教育学院教案与讲稿 2 Teaching Plan for International Students, AHMU Title of the course: Drug therapy in pregant and nursing women Chapter: 22 Teacher’s name: Chang Yan Grade: 2013 Department: Clinical Medicine, School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/30/2016 Lecture Notes: 【Raise a question】 1 min What are special populations? 【Show date】 1 min WHO survey showed that 89% of women take prescription drugs during pregnancy (avg = 3 prescription each) not including OTC preparation and alternative therapies 【Physiologial Changes in Pregnancy】 8 min
Gastrointestinal changes
Cardiovascular system changes
Decrease in albumin concentration
Enzymatic activity changes
Increase in glomerular filtration rate (GFR) Give examples: Phenytoin 【Maternal Physiologic Changes Altering PK of Drugs】 10 min
Volume Expansion
Protein binding-increase in free fraction of drugs bound to albumin
Clearance changes
Gastrointestinal changes Give examples: Caffeine; Theophylline; Methadone; Ampicllin 【Drug Studies for Pregnancy】 6 min Pregnancy Specific Drugs
Tocolytic agents
Oxytocic agents