4. Which of the following clinical features are not characteristic of famil ial cancer syndromes? A. Two or more independent primary tumors in a single individual B. More often involve mutation in tumor suppressor genes than oncogenes C One or more close relatives are affected by the same rare tumor D Observed tumor types are rarely seen as sporad ic cancers E. Earlier mean age of cancer onset, compared to sporadic form of the same tumor type 5. Each of the following have been observed as mechan isms resulting in the activation of a proto-oncogene EXCEPT A. A chromosome trans location fusing portions of the oncogene and another cellular B Inactivation of an oncogene by epigenetic modification C. a point mutation altering the function of the oncogene protein product D. Capture of the oncogene sequence by a retrovirus E. Amplification of an oncogene as small, sub-chromosomal fragments(double minutes) 6. Approximately how many base pairs are found in the human haploid genome? A6,200,000(62 million) B6,200000,000(62 billion) C6,200,000000062 trillion) D3,100000,000(3.1 billion) E3,100,0000000003. I trillion) 7. Which genomic component is often used to produce DNA"fingerprints"of individuals for use in legal proceedings? A copy number variants(CNVs) B single nucleotide polymorphism(SNPs) D euchromatin E telomere 8. How many chromosomes comprise the normal human karyotype? 48 autosomal chromosomes plus 2"sex"chromosomes B46 autosomal chromosomes plus 2"sex"chromosome C 44 autosomal chromosomes plus 2"sex"chromosomes D42 autosomal chromosomes plus 2"sex chromosomes E40 autosomal chromosomes plus 2"sex"chromosomes4. Which of the following clinical features are NOT characteristic of familial cancer syndromes? A. Two or more independent primary tumors in a single individual B. More often involve mutation in tumor suppressor genes than oncogenes C. One or more close relatives are affected by the same rare tumor D. Observed tumor types are rarely seen as sporadic cancers E. Earlier mean age of cancer onset, compared to sporadic form of the same tumor type 5. Each of the following have been observed as mechanisms resulting in the activation of a proto-oncogene EXCEPT: A. A chromosome translocation fusing portions of the oncogene and another cellular gene B. Inactivation of an oncogene by epigenetic modification C. A point mutation altering the function of the oncogene protein product D. Capture of the oncogene sequence by a retrovirus E. Amplification of an oncogene as small, sub-chromosomal fragments (double minutes) 6. Approximately how many base pairs are found in the human haploid genome? A 6,200,000 (6.2 million) B 6,200,000,000 (6.2 billion) C 6,200,000,000,000 (6.2 trillion) D 3,100,000,000 (3.1 billion) E 3,100,000,000,000 (3.1 trillion) 7. Which genomic component is often used to produce DNA “fingerprints” of individuals for use in legal proceedings? A copy number variants (CNVs) B single nucleotide polymorphism (SNPs) C microsatellites D euchromatin E telomeres 8. How many chromosomes comprise the normal human karyotype? A 48 autosomal chromosomes plus 2 “sex” chromosomes B 46 autosomal chromosomes plus 2 “sex” chromosomes C 44 autosomal chromosomes plus 2 “sex” chromosomes D 42 autosomal chromosomes plus 2 “sex” chromosomes E 40 autosomal chromosomes plus 2 “sex” chromosomes