9. Which of the following cannot be explained by abnormal recombination? A Robersonian translocations B unbalanced translocations Ci nversions d deletions E point mutation 10. Which of the following is a false statement? A Methy lation of dNA most frequently occurs on C residues in CpG dinucleotides B Methy lated DNA is usually associated with open, transcriptionally active chromatin C Methy lated dNa is usually associated with compact, transcriptionally inactive chromatin D Chromosomal Imprinting involves the transmission of methylated DNA from parents to their offspring E DNA methy lation is one of the mechanisms underlying"epigenetic"regulation of gene expression 11. Which of the following is a false statement? A The enzyme telomerase catalyzes the shortening of chromosomal telomeres B The enzyme telomerase catalyzes the lengthening of chromosomal telomeres C In many types of cells, telomeres become a little shorter with each cell division. D The progressive shortening of telomeres is caused by the inability to prime synthesis of the agging dna strand E Abnormal shortening of telomeres causes chromosome instability and cell death. 12. Which of the following is a false statement? A Prader-Willi syndrome is often caused by the loss of the ability to express genes from the paternally inherited chromosome that cannot be expressed from the maternally inherited hromosome due to imprinting B Prader-Willi syndrome is often caused by the loss of the ability to express genes from the maternally inherited chromosome that cannot be expressed from the paternally inherited chromosome due to imprinting C Angelman syndrome is often caused by the loss of the ability to express genes from the maternally inherited chromosome that cannot be expressed from the paternally inherited chromosome due to imprinting. d Loss of paternally expressed genes can be caused by: i)deletions of the paternal chromosome, ii) maternal uniparental disomy or iii)imprinting defects in the paternally inherited chromosome E Angelman syndrome can also be caused by point mutations in the UBE3 gene 13. Which of the following statements is false a penetrance refers the to the percentage of individuals who carry a disease-causing mutation who show have symptoms of the disease, regardless of the severity of the sympt B penetrance is a measure of the severity of symptoms experienced by individuals who carry a disease-causing mutation. C expressivity is a measure of the severity of symptoms experienced by individuals who carry a disease-causing mutation.9. Which of the following cannot be explained by abnormal recombination? A Robersonian translocations B unbalanced translocations Ci nversions D deletions E point mutations 10. Which of the following is a false statement? A Methylation of DNA most frequently occurs on C residues in CpG dinucleotides. B Methylated DNA is usually associated with open, transcriptionally active chromatin. C Methylated DNA is usually associated with compact, transcriptionally inactive chromatin. D Chromosomal Imprinting involves the transmission of methylated DNA from parents to their offspring. E DNA methylation is one of the mechanisms underlying “epigenetic” regulation of gene expression. 11. Which of the following is a false statement? A The enzyme telomerase catalyzes the shortening of chromosomal telomeres. B The enzyme telomerase catalyzes the lengthening of chromosomal telomeres. C In many types of cells, telomeres become a little shorter with each cell division. D The progressive shortening of telomeres is caused by the inability to prime synthesis of the lagging DNA strand. E Abnormal shortening of telomeres causes chromosome instability and cell death. 12. Which of the following is a false statement? A Prader-Willi syndrome is often caused by the loss of the ability to express genes from the paternally inherited chromosome that cannot be expressed from the maternally inherited chromosome due to imprinting. B Prader-Willi syndrome is often caused by the loss of the ability to express genes from the maternally inherited chromosome that cannot be expressed from the paternally inherited chromosome due to imprinting. C Angelman syndrome is often caused by the loss of the ability to express genes from the maternally inherited chromosome that cannot be expressed from the paternally inherited chromosome due to imprinting. D Loss of paternally expressed genes can be caused by: i) deletions of the paternal chromosome, ii) maternal uniparental disomy or iii) imprinting defects in the paternally inherited chromosome. E Angelman syndrome can also be caused by point mutations in the UBE3 gene. 13. Which of the following statements is false? A penetrance refers the to the percentage of individuals who carry a disease-causing mutation who show have symptoms of the disease, regardless of the severity of the symptoms. B penetrance is a measure of the severity of symptoms experienced by individuals who carry a disease-causing mutation. C expressivity is a measure of the severity of symptoms experienced by individuals who carry a disease-causing mutation