a consist of four subunits B are glycoproteins c have inter- and intra-chain d sulfide crosslinks d are secreted into the blood stream E All four choices are correct 3. The immunoglobulin fold a found only in Igg molecules b composed of two antiparallel b-strands folded into a globular domain c a b-barrel composed of a three -and a four-stranded antiparallel b-sheet d found six times in the lgg molecule e The third and fourth choices are both correct 4. Antigenic determinants bind to which portions of an antibody? a variable regions B constant regions c only light chain d only heavy chains e the effector region 5. Monoclonal antibod ies produced in the laboratory a lack the constant regions of IgG b cannot be used for disease diagnosis yet c derive from human cancer patients d can be selected to bind to almost any known molecule e None of the above are correct 6. Antibodies in the human immune system can identify approximately 108 different molecules. Which one of the following is true? a This diversity is generated from 108 different immunoglobin genes b Most of these antibodies recognize self-antigens C Most of these antibodies recognize proteins. D Most of these antibodies recognize small organic molecules e There are really just a small number of antibodies, each of which can bind to many different antiger gon ※<8 1. The specificity of a ligand bind ing site on a protein is based on a the absence of competing ligands b the amino acid residues lining the bind ing site. c the presence of hydrating water moleculesA consist of four subunits. B are glycoproteins. C have inter- and intra-chain disulfide crosslinks. D are secreted into the bloodstream. E All four choices are correct. 3. The immunoglobulin fold is A found only in IgG molecules. B composed of two antiparallel b-strands folded into a globular domain. C a b-barrel composed of a three- and a four-stranded antiparallel b-sheet. D found six times in the IgG molecule. E The third and fourth choices are both correct. 4. Antigenic determinants bind to which portions of an antibody? A variable regions. B constant regions. C only light chains. D only heavy chains. E the effector region. 5. Monoclonal antibodies produced in the laboratory A lack the constant regions of IgG. B cannot be used for disease diagnosis yet. C derive from human cancer patients. D can be selected to bind to almost any known molecule. E None of the above are correct. 6. Antibodies in the human immune system can identify approximately 108 different molecules. Which one of the following is true? A This diversity is generated from 108 different immunoglobin genes. B Most of these antibodies recognize self-antigens. C Most of these antibodies recognize proteins. D Most of these antibodies recognize small organic molecules. E There are really just a small number of antibodies, each of which can bind to many different antigens. F have gone unnoticed. 5 ※<8> 1. The specificity of a ligand binding site on a protein is based on: A the absence of competing ligands. B the amino acid residues lining the binding site. C the presence of hydrating water molecules