BEH. 462/3.962J Molecular Principles of Biomaterials Spring 2003 Structure of vasculature blood vessel structure Endothelial cell lining Smooth muscle pO2 Blood flow (supportive ECM Extensive cell death in center of construct · Angiogenesis° enchymal cell tins are clearly implicated, though their precise Mature Angiogonosiz PDGF日 Steps in angiogenesis 1. VEGF(vascular endothelial growth factor) - attracts endothelial cells, induces proliferation -induces tube formation 2. PDGF(platelet-derived growth factor) -attracts smooth muscle cells stabilizes new vessels Lecture 5- Programmed Drug Delivery 8 of 12BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Lecture 5 – Programmed Drug Delivery 8 of 12 • Structure of vasculature O2 O2 O2 z pO2 Blood flow blood vessel structure: Intima (supportive ECM layer) Endothelial cell lining Smooth muscle cells Extensive cell death in center of construct • Angiogenesis8 Steps in angiogenesis: 1. -attracts endothelial cells, induces proliferation -induces tube formation 2. -attracts smooth muscle cells, stabilizes new vessels VEGF (vascular endothelial growth factor) PDGF (platelet-derived growth factor)