Neurofibrillary Tangle I This is a neurofibrillary tangle of Alzheimer's disease.The tangle appears as long pink filaments in the cytoplasm. They are composed of cytoskeletal intermediate filaments.Neurofibrillary Tangle This is a neurofibrillary tangle of Alzheimer's disease. The tangle appears as long pink filaments in the cytoplasm. They are composed of cytoskeletal intermediate filaments