一个基因可编编码两种完全不同的蛋白质 p16Ink4a E E1 a P14 ARF(human) P19 ARF (mouse) Cross Talk between Oncogenes tumor suppressors Oncogenic Signals Ras, c-myc, E2F P14 p16nk4a (Block MDM-2/ p53 binding) DNA Damage Cell cycle arrest 2YY制作ZYY制作 4 E1 b E1 a Exon 2 Exon 3 p16 Ink 4a P14 ARF (human) P19 ARF (mouse) Cross Talk betweren Oncogenes & tumor suppressors Oncogenic Signals Ras, c-myc, E2F p16 Ink 4a Rb on Cell cycle arrest P14 ARF (Block MDM-2 / p53 binding) p53 on DNA Damage 一个基因可编编码两种完全不同的蛋白质