Thr NEW ENGLAND JOURNAL Of MEDICINE (0S-0'sS 09t (059-008)07S a 16.99)r6/t6 ()6/ 255925/005 6uo16101 6 -840 O'85-0'SE)O 215501 6)66095 (E)99/6 E811500 (S'E)8o/8 88)66070 'ou >a 6 N ENGLJ MED NEJM.ORG OUTERN MEDCAL UNTVTY .No other useswithout p opyngnt 2026 n engl j med nejm.org The new england journal o f medicine Table 1. Clinical Characteristics of the Study Patients, According to Disease Severity and the Presence or Absence of the Primary Composite End Point.* Characteristic All Patients (N=1099) Disease Severity Presence of Primary Composite End Point† Nonsevere (N=926) Severe (N=173) Yes (N=67) No (N=1032) Age Median (IQR) — yr 47.0 (35.0–58.0) 45.0 (34.0–57.0) 52.0 (40.0–65.0) 63.0 (53.0–71.0) 46.0 (35.0–57.0) Distribution — no./total no. (%) 0–14 yr 9/1011 (0.9) 8/848 (0.9) 1/163 (0.6) 0 9/946 (1.0) 15–49 yr 557/1011 (55.1) 490/848 (57.8) 67/163 (41.1) 12/65 (18.5) 545/946 (57.6) 50–64 yr 292/1011 (28.9) 241/848 (28.4) 51/163 (31.3) 21/65 (32.3) 271/946 (28.6) ≥65 yr 153/1011 (15.1) 109/848 (12.9) 44/163 (27.0) 32/65 (49.2) 121/946 (12.8) Female sex — no./total no. (%) 459/1096 (41.9) 386/923 (41.8) 73/173 (42.2) 22/67 (32.8) 437/1029 (42.5) Smoking history — no./total no. (%) Never smoked 927/1085 (85.4) 793/913 (86.9) 134/172 (77.9) 44/66 (66.7) 883/1019 (86.7) Former smoker 21/1085 (1.9) 12/913 (1.3) 9/172 (5.2) 5/66 (7.6) 16/1019 (1.6) Current smoker 137/1085 (12.6) 108/913 (11.8) 29/172 (16.9) 17/66 (25.8) 120/1019 (11.8) Exposure to source of transmission within past 14 days — no./ total no. Living in Wuhan 483/1099 (43.9) 400/926 (43.2) 83/173 (48.0) 39/67 (58.2) 444/1032 (43.0) Contact with wildlife 13/687 (1.9) 10/559 (1.8) 3/128 (2.3) 1/41 (2.4) 12/646 (1.9) Recently visited Wuhan‡ 193/616 (31.3) 166/526 (31.6) 27/90 (30.0) 10/28 (35.7) 183/588 (31.1) Had contact with Wuhan residents‡ 442/611 (72.3) 376/522 (72.0) 66/89 (74.2) 19/28 (67.9) 423/583 (72.6) Median incubation period (IQR) — days§ 4.0 (2.0–7.0) 4.0 (2.8–7.0) 4.0 (2.0–7.0) 4.0 (1.0–7.5) 4.0 (2.0–7.0) Fever on admission Patients — no./total no. (%) 473/1081 (43.8) 391/910 (43.0) 82/171 (48.0) 24/66 (36.4) 449/1015 (44.2) Median temperature (IQR) — °C 37.3 (36.7–38.0) 37.3 (36.7–38.0) 37.4 (36.7–38.1) 36.8 (36.3–37.8) 37.3 (36.7–38.0) Distribution of temperature — no./total no. (%) <37.5°C 608/1081 (56.2) 519/910 (57.0) 89/171 (52.0) 42/66 (63.6) 566/1015 (55.8) 37.5–38.0°C 238/1081 (22.0) 201/910 (22.1) 37/171 (21.6) 10/66 (15.2) 228/1015 (22.5) 38.1–39.0°C 197/1081 (18.2) 160/910 (17.6) 37/171 (21.6) 11/66 (16.7) 186/1015 (18.3) >39.0°C 38/1081 (3.5) 30/910 (3.3) 8/171 (4.7) 3/66 (4.5) 35/1015 (3.4) Fever during hospitalization Patients — no./total no. (%) 975/1099 (88.7) 816/926 (88.1) 159/173 (91.9) 59/67 (88.1) 916/1032 (88.8) Median highest temperature (IQR) — °C 38.3 (37.8–38.9) 38.3 (37.8–38.9) 38.5 (38.0–39.0) 38.5 (38.0–39.0) 38.3 (37.8–38.9) <37.5°C 92/926 (9.9) 79/774 (10.2) 13/152 (8.6) 3/54 (5.6) 89/872 (10.2) 37.5–38.0°C 286/926 (30.9) 251/774 (32.4) 35/152 (23.0) 20/54 (37.0) 266/872 (30.5) 38.1–39.0°C 434/926 (46.9) 356/774 (46.0) 78/152 (51.3) 21/54 (38.9) 413/872 (47.4) >39.0°C 114/926 (12.3) 88/774 (11.4) 26/152 (17.1) 10/54 (18.5) 104/872 (11.9) The New England Journal of Medicine Downloaded from nejm.org at SOUTHERN MEDICAL UNIVERSITY on March 6, 2020. For personal use only. No other uses without permission. Copyright © 2020 Massachusetts Medical Society. All rights reserved