Continuous(multiple)dose kinetics A drug administered intermittently will accumulate to a steady state at the same rate as a drug given by continuous infusion,but the plasma drug concentration will fluctuate as each dose is absorbed and eliminated.The average steady-state plasma drug concentration with intermittent intravenous administration will be the same as if the equivalent dose were administered by continuous infusion. With intermittent oral administration,the bioavailability of the drug will also influence the steady-state plasma concentration.Continuous (multiple) dose kinetics • A drug administered intermittently will accumulate to a steady state at the same rate as a drug given by continuous infusion, but the plasma drug concentration will fluctuate as each dose is absorbed and eliminated. The average steady‐state plasma drug concentration with intermittent intravenous administration will be the same as if the equivalent dose were administered by continuous infusion. With intermittent oral administration, the bioavailability of the drug will also influence the steady‐state plasma concentration