INTERFERON+IFNR 2-5(A)synthetase expression PKR expression Hs∨-1 Active RNaseL Active PKR Protein (phosphatase Other cP345 mRNa degradation substrates eIF-2o eIF-2a Inhibition of Inhibition of protein synthesis protein synthesis Protein synthesis Viral Viral Viral replIcaTion replicaTion blocked blocked replication