Type ll (gamma) (alpha, beta) TypeⅢl IFN (ambda) …RR2 IFNAR NAR2 Cytoplasm JAK1 JAK1 TYK2 JAK1 TYK2 STATiS STATZ STAT1 STAT1 STAT1 STAT2 IRF9 IRF9 Nucleus ISGs STAT1 STAT ISRE GAS interferon signaling Frontiers in Bioscience 14, 4950-4961, 2009.Interferon signaling Frontiers in Bioscience 14, 4950-4961, 2009