Rational Dosing the Time Course of Drug Action Total hours required 6 Total Classes required= Days of Study Thu Period ofStudy Week 1&2-First semester a.Lecture 1 Class V i.PHARMACOKINETICS a.Volume of Distribution b.Clearance i.Capacity-Limited Elimination ii.Flow-Dependent Elimination c.Half-Life d.Drug Accumulation b.Lecture 2 Clas s V i.PHARMACOKINETICS e.Bioavailability i.Extent of Absorption ii.First-Pass Elimination iii.Rate of Absorption f.Extraction Ratio the First-Pass Effect g.Alternative Route of Administration the First-Pass Effect ii.THE TIME COURSE OF DRUG EFFECT a.Immediate Effects b.Delayed Effects c.Cumulative Effects iii.THE TARGET CONCENTRATION APPROACH TO N G A RATIONAL DOSAGE REGIMEN a.Maintenance Dose b.Loading Dose c.Lecture3 Class VⅢ i..THERAPEUTIC DRUG MONITORING:RELATING PHARMACOKINETICS OPHARMACODYNAMICS a.Pharmacokinetic Variables i.Absorption Rational Dosing & the Time Course of Drug Action Total hours required = 6 Total Classes required = 3 Days of Study = Thu Period of Study = Week 1&2 –First semester a. Lecture 1 Class V i. PHARMACOKINETICS a. Volume of Distribution b. Clearance i. Capacity-Limited Elimination ii. Flow-Dependent Elimination c. Half-Life d. Drug Accumulation b. Lecture 2 Class VI i. PHARMACOKINETICS e. Bioavailability i. Extent of Absorption ii. First-Pass Elimination iii. Rate of Absorption f. Extraction Ratio & the First-Pass Effect g. Alternative Route of Administration & the First-Pass Effect ii. THE TIME COURSE OF DRUG EFFECT a. Immediate Effects b. Delayed Effects c. Cumulative Effects iii. THE TARGET CONCENTRATION APPROACH TO D E S I G N I N G A RATIONAL DOSAGE REGIMEN a. Maintenance Dose b. Loading Dose c. Lecture 3 Class VII i.. THERAPEUTIC DRUG MONITORING: RELATING PHARMACOKINETICS & OPHARMACODYNAMICS a. Pharmacokinetic Variables i. Absorption