Oral rectal transdermal. mucosal injecting, perineural, and patient self control administration are the clinical administration for varies patients. Every path has its advantage and disadvantage for right person NcCN provides a detail guideline for pain management in clinic• Oral, rectal, transdermal, mucosal, injecting, perineural, and patient self￾control administration are the clinical administration for varies patients. Every path has its advantage and disadvantage for right person. • NCCN provides a detail guideline for pain management in clinic