Oral rectal transdermal. mucosal injecting, perineural, and patient self control administration are the clinical administration for varies patients. Every path has its advantage and disadvantage for right person NcCN provides a detail guideline for pain management in clinic• Oral, rectal, transdermal, mucosal, injecting, perineural, and patient selfcontrol administration are the clinical administration for varies patients. Every path has its advantage and disadvantage for right person. • NCCN provides a detail guideline for pain management in clinic