Fluid, Electrolyte Acid-base Disorders C. Metabolic acidosis Pathogeny 1. The lose of large amount of basic substances (gastrointestinal tract kidnevs 2. Too much Acid metabolite (hungriness, diabetes, renal failure, hypoxia) 3. Too much acid substance intake (long time to take calcium chloride ammonium chloride, amino acid etc.) D egree Mild HCO2 18-13 mmol /L Moderate HCO 13-9 mmol /L Severe HCO3 <9 mmol/LC. Metabolic acidosis Pathogeny 1. The lose of large amount of basic substances（gastrointestinal tract, kidneys） 2. Too much Acid metabolite （hungriness, diabetes, renal failure, hypoxia） 3. Too much acid substance intake （long time to take calcium chloride, ammonium chloride, amino acid etc.） Degree Mild HCO3 - 18~13 mmol / L Moderate HCO3 - 13~9 mmol / L Severe HCO3 - <9 mmol / L Fluid, Electrolyte & Acid-base Disorders