Journal of Natural Product Table 2.continued 1iananaeil.beioi0 ACWY- 911202 A.TT le typhoid va Typheri ONP 12 35 of the educed level of products in spite 人ed2012.75311-35the physician. Inspection of the data shows the continued important role for natural products in spite of the current greatly reduced level of natural products-based drug discovery programs in major pharmaceutical houses. Table 2. continued generic name trade name year introduced volume page source moxalactam disodium Shiomarin 1982 I 070301 ND panipenem/betamipron Carbenin 1994 ARMC 30 305 ND quinupristin Synercid 1999 ARMC 35 338 ND retapamulin Altabax 2007 ARMC 43 486 ND rifabutin Mycobutin 1992 ARMC 28 335 ND rifamixin Normix 1987 ARMC 23 341 ND rifapentine Rifampin 1988 ARMC 24 310 ND rifaximin Rifacol 1985 ARMC 21 332 ND rokitamycin Ricamycin 1986 ARMC 22 325 ND roxithromycin Rulid 1987 ARMC 23 342 ND sultamycillin tosylate Unasyn 1987 ARMC 23 343 ND tazobactam sodium Tazocillin 1992 ARMC 28 336 ND telavancin HCl Vibativ 2009 DNP 23 15 ND telithromycin Ketek 2001 DNP 15 35 ND temocillin disodium Temopen 1984 ARMC 20 323 ND tigecycline Tygacil 2005 DNP 19 42 ND balafloxacin Q-Roxin 2002 ARMC 38 351 S besifloxacin Besivance 2009 DNP 23 20 S ciprofloxacin Ciprobay 1986 ARMC 22 318 S enoxacin Flumark 1986 ARMC 22 320 S fleroxacin Quinodis 1992 ARMC 28 331 S garenoxacin Geninax 2007 ARMC 43 471 S gatilfloxacin Tequin 1999 ARMC 35 340 S gemifloxacin mesilate Factive 2003 ARMC 40 458 S grepafloxacin Vaxor 1997 DNP 11 23 S levofloxacin Floxacin 1993 ARMC 29 340 S linezolid Zyvox 2000 DNP 14 21 S lomefloxacin Uniquin 1989 ARMC 25 315 S moxifloxacin HCl Avelox 1999 ARMC 35 343 S nadifloxacin Acuatim 1993 ARMC 29 340 S norfloxacin Noroxin 1983 ARMC 19 322 S ofloxacin Tarivid 1985 ARMC 21 331 S pazufloxacin Pasil 2002 ARMC 38 364 S pefloxacin mesylate Perflacine 1985 ARMC 21 331 S prulifloxacin Sword 2002 ARMC 38 366 S rufloxacin hydrochloride Qari 1992 ARMC 28 335 S sitafloxacin hydrate Gracevit 2008 DNP 22 15 S sparfloxacin Spara 1993 ARMC 29 345 S taurolidine Taurolin 1988 I 107771 S temafloxacin hydrochloride Temac 1991 ARMC 27 334 S tosufloxacin Ozex 1990 ARMC 26 310 S trovafloxacin mesylate Trovan 1998 ARMC 34 332 S brodimoprin Hyprim 1993 ARMC 29 333 S*/NM ACWY meningoccal PS vaccine Mencevax 1981 I 420128 V DTPw-HepB-Hib Quinvaxem 2006 DNP 20 26 V H. influenzae b vaccine Hibtitek 1989 DNP 03 24 V H. influenzae b vaccine Prohibit 1989 DNP 03 24 V MCV-4 Menactra 2005 DNP 19 43 V menACWY-CRM Menveo 2010 I 341212 V meningitis b vaccine MeNZB 2004 DNP 18 29 V meningococcal vaccine Menigetec 1999 DNP 14 22 V meningococcal vaccine NeisVac-C 2000 DNP 14 22 V meningococcal vaccine Menjugate 2000 DNP 14 22 V oral cholera vaccine Orochol 1994 DNP 08 30 V pneumococcal vaccine Prevnar 2000 DNP 14 22 V PsA-TT MenAfriVac 2010 I 437718 V vi polysaccharide typhoid vaccine Typherix 1998 DNP 12 35 V Journal of Natural Products Review 318 dx.doi.org/10.1021/np200906s | J. Nat. Prod. 2012, 75, 311−335