0-1D multi-scale modeling of the cardiovasculansystem SHANGHAI JIAO TONG UNIVERSITY Coronary arterial RCA tree(1-D model) Aorta 9:999999999999999999999999999999999999 Left Coronary Artery Right Coronary Artery Circumflex Artery Left Anteno Descending Artery Intramyocardial pressure 0-D model Interface!1-D model Cerebral artery network(1-D model) 64 Right 3 Left 62 Right Right 82 atrium ventricle Superor A closed-loop model that describes both arterial wave vena cava propagation and systemic hemodynamics Liver Inferior vena cava Kidneys Intestines and spleen Abdominal Lower limbs vena cava 5 ① [Liang,et al.Medical Biological Engineering Computing.2009] [Liang,et al.Biomedical Engineering Online.2011] [Liang,et al.Journal of Biomechanics.2009]0-1D multi-scale modeling of the cardiovascular system Coronary arterial tree (1-D model) Intramyocardial pressure A closed-loop model that describes both arterial wave propagation and systemic hemodynamics RCA LAD LCX [Liang, et al. Medical & Biological Engineering & Computing. 2009] [Liang, et al. Journal of Biomechanics. 2009] Aorta [Liang, et al. Biomedical Engineering Online. 2011]