干扰傖号传导途径 Type I IFN Type Ill IFN -Type II IFN IFNARI IFNAR2 接受信号 Plas IL-10R2 IFNLRI brane FNGR2 IFNGRI Cytoplasm(K2 JAKI (AK2 JAKSTAT pathway 传递信号 ISGF3 IRF9 Nucleus ISG: Interfero MX. OAS 效应基因 Stimulated F and PKR 表达 Antimycobacterial Gene immunity Antiviral immunity Nat Rev Immunol. 2008. 8: 559Nat Rev Immunol. 2008, 8:559 JAK/STAT pathway ISG: Interferon Stimulated Gene 干扰素信号传导途径 传递信号 效应基因 表达 接受信号