3、改造天然产物 HO H3C acetyl CoA CoA HMG CoA reductase OH cholesterol NADPH Km=10uM HO 01 OH LDL-C:引起动脉粥状样硬化、心肌梗死 桔青霉Penicillium citrinum提纯得到Lovastatin HO HO OH OH O H H3C 三 H CH3 CH3 CH3 H CH3 HaC HgC Lovastatin K=1nM 3、改造天然产物 LDL-C: 引起动脉粥状样硬化、心肌梗死 桔青霉Penicillium citrinum提纯得到Lovastatin acetyl CoA O OH O HO H3C S CoA HMG CoA reductase NADPH O OH HO HO CH3 cholesterol O O O HO O CH3 H3C CH3 H3C H H H O OH O HO O CH3 H3C CH3 H3C H H H OH Lovastatin Ki = 1nM Km =10mM