五、 更新或补充内容提要 六、 复习思考题 1.How do pKa and lipid solubility affect drug absorption? 2.What is the predominant transport mode for absorption of most commercial drugs? 3.Which of the following structural modifications likely will improve permeability? (a)change an amine to a methyl;(b)add a methoxy groups;(c)remove a propyl group;(d)change a carboxylic acid to en ethyl ester;(e)change a carboxylic acid to a terazole. 4.Which parameters are used to describe PK? 5.Descibe the type of prodrug,the purpose of prodrug design,and provide examples to explain how to design prodrug? 七、 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期肝刊的名称及内容等 《药物化学》尤启冬主编，化学工业出版社，第三版五、 更新或补充内容提要 六、 复习思考题 1. How do pKa and lipid solubility affect drug absorption? 2. What is the predominant transport mode for absorption of most commercial drugs? 3. Which of the following structural modifications likely will improve permeability? (a) change an amine to a methyl; (b) add a methoxy groups; (c) remove a propyl group; (d) change a carboxylic acid to en ethyl ester; (e) change a carboxylic acid to a terazole. 4. Which parameters are used to describe PK? 5. Descibe the type of prodrug, the purpose of prodrug design, and provide examples to explain how to design prodrug? 七、 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等 《药物化学》尤启冬主编，化学工业出版社，第三版