《体育科学》2020年(第40卷)第4期 [J]. J Bone miner res,26(10):2552-2563. WEILBAECHER K N. MOTYCKOVA G. HUBER WE. et al TOBEL J, KUNTZ L, MARTHEN C, et al.. 2016 Methylation of the :001. Linkage of M-CSF signaling to Mitf. TFE3. and the ER-alpha promoter is influenced by its ligand estrogen in osteoclast defect in Mitf( mi/mi)mice[J]. Mol Cell. 8(4):749- osteosarcoma cells SAOS-2 in vitro [J]. Anticancer Res, 36(6) WHITE AJ. SANDLER D P. BOLICK s C. et al 3199-3204 Recreational and household physical activity at different time points TURNER C H. 1992. Functional determinants of bone structure and DNA global methylation[J]. Eur J Cancer, 49(9): 2199-2206 Beyond Wolffs law of bone transformation [J]. Bone, 13(6) YAVROPOULOU MP. ANASTASILAKIS AD. MAKRAS P et al 403-409 2017. Expression of microRNAs that regulate bone turnover in the VALENTE-DOS-SANTOS J. TAVARES OM. DUARTE JP et al serum of postmenopausal women with low bone mass and vertebral 2018. Total and regional bone mineral and tissue composition in fractures[J].Eur J Endocrinol. 176(2):169-176 female adolescent athletes: Comparison between volley ball players YOON D S. CHOI Y, JANG Y. et al., 2014. SIRTI directly regulates and swimmers[J]. BMC Pediatr, 18(1): 1-11 SOX2 to maintain self-renewal and multipotency in bone marrow VON WEBSKYK. HASAN AA. REICHETZEDER C. et al 2018 derived mesenchymal stem cells[J]. Stem Cells, 32(12): 3219-3231 Impact of vitamin D on pregnancy-related disorders and YUAN Y. ZHANG L. TONG X. et al. 2017. Mechanical stress offspring outcome[ J].J Steroid Biochem Mol Biol. 180: 51-64 regulates bone metabolism through microRNAs[J]. J Cell Physiol WANG P. CAO Y. ZHAN D, et al. 2018. Influence of DNA 232(6): 1239-1245 methylation on the expression of OPG/RANKL in primary ZHOU M, MA J, CHEN S, et al., 2014. microRNA-17-92 cluster osteoporosis[J]. Int J Med Sci, 15(13):1480-1485 regulates osteoblast proliferation and differentiation[J].Endocrine WEI F, YANG S. GUO Q. et al., 2017. microRNA-21 regulates 45(2):302-310 osteogenic differentiation of periodontal ligament stem cells by ZIMMER P, SCHENK A, BLOCH W. 2016. Medical Epigenetics rgeting Smad5[J]. Sci Rep. 7(1): 1-12 [M].Amsterdam. Netherlands: Elsevier Inc Research Progress on Epigenetic Mechanism of the Effect of Exercise on Bone HU Xiaopan", LI Shichang., SUN Peng I. Key laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China norma University, Shanghai 200241, China, 2. College of Physical Education and Health East China Normal University, Shanghai 200241, China. Abstract: Besides gender, age, hormone levels, lifestyle, and mechanical stress, the changes of bone health are also related to the epigenetic regulation pathways. The three main pathways of epigenetic regulation include DNA methylation, histone modification, and non-coding RNA. In the genetic-environment category, as an exogenous mechanical stimulus, exercise can promote bone formation by regulating dna demethylation, regulate histone modifications to support bone homeostasis, and regulate non-coding- RNA to affect bone metabolic pathways. All of the abovementioned pathways are possible mechanisms for improving bone health through epigenetic pathways. The article reviews the recent advances in the research of epigenetic regulation in the field of bone tissue sports medicine, and it will provide new ideas for bone strengthening and prevention of metabolic diseases such as osteoporosis Keywords: epigenetics; osteoporosis; exercise: bone metabolism; DNA methylation: histone modifications: non-coding RNAs 66《体育科学》2020 年（第 40 卷）第 4 期 ［J］. J Bone Miner Res，26（10）：2552-2563. TÜBEL J，KUNTZ L，MARTHEN C，et al.，2016. Methylation of the ER-alpha promoter is influenced by its ligand estrogen in osteosarcoma cells SAOS-2 in vitro［J］. Anticancer Res，36（6）： 3199-3204. TURNER C H，1992. Functional determinants of bone structure： Beyond Wolff’s law of bone transformation［J］. Bone，13（6）： 403-409. VALENTE-DOS-SANTOS J，TAVARES Ó M，DUARTE J P，et al.， 2018. Total and regional bone mineral and tissue composition in female adolescent athletes：Comparison between volleyball players and swimmers［J］. BMC Pediatr，18（1）：1-11. VON WEBSKY K ，HASAN A A，REICHETZEDER C，et al.，2018. Impact of vitamin D on pregnancy-related disorders and on offspring outcome［J］. J Steroid Biochem Mol Biol，180：51-64. WANG P，CAO Y，ZHAN D，et al.，2018. Influence of DNA methylation on the expression of OPG/RANKL in primary osteoporosis［J］. Int J Med Sci，15（13）：1480-1485. WEI F，YANG S，GUO Q，et al.，2017. microRNA-21 regulates osteogenic differentiation of periodontal ligament stem cells by targeting Smad5［J］. Sci Rep，7（1）：1-12. WEILBAECHER K N，MOTYCKOVA G，HUBER W E，et al.， 2001. Linkage of M-CSF signaling to Mitf， TFE3， and the osteoclast defect in Mitf（mi/mi）mice［J］. Mol Cell，8（4）：749-758. WHITE A J， SANDLER D P， BOLICK S C， et al.，2013. Recreational and household physical activity at different time points and DNA global methylation［J］. Eur J Cancer，49（9）：2199-2206. YAVROPOULOU M P，ANASTASILAKIS A D，MAKRAS P，et al.， 2017. Expression of microRNAs that regulate bone turnover in the serum of postmenopausal women with low bone mass and vertebral fractures［J］. Eur J Endocrinol，176（2）：169-176. YOON D S，CHOI Y，JANG Y，et al.，2014. SIRT1 directly regulates SOX2 to maintain self-renewal and multipotency in bone marrow￾derived mesenchymal stem cells［J］. Stem Cells，32（12）：3219-3231. YUAN Y，ZHANG L，TONG X，et al.，2017. Mechanical stress regulates bone metabolism through microRNAs［J］. J Cell Physiol， 232（6）：1239-1245. ZHOU M，MA J，CHEN S，et al.，2014. microRNA-17-92 cluster regulates osteoblast proliferation and differentiation［J］. Endocrine， 45（2）：302-310. ZIMMER P，SCHENK A，BLOCH W，2016. Medical Epigenetics ［M］. Amsterdam，Netherlands：Elsevier Inc. Research Progress on Epigenetic Mechanism of the Effect of Exercise on Bone HU Xiaopan1，2 ，LI Shichang1，2*，SUN Peng1，2 1. Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education，East China Normal University，Shanghai 200241，China; 2. College of Physical Education and Health， East China Normal University，Shanghai 200241，China. Abstract: Besides gender, age, hormone levels, lifestyle, and mechanical stress, the changes of bone health are also related to the epigenetic regulation pathways. The three main pathways of epigenetic regulation include DNA methylation, histone modification, and non-coding RNA. In the genetic-environment category, as an exogenous mechanical stimulus, exercise can promote bone formation by regulating DNA demethylation, regulate histone modifications to support bone homeostasis, and regulate non-coding￾RNA to affect bone metabolic pathways. All of the abovementioned pathways are possible mechanisms for improving bone health through epigenetic pathways. The article reviews the recent advances in the research of epigenetic regulation in the field of bone tissue sports medicine, and it will provide new ideas for bone strengthening and prevention of metabolic diseases such as osteoporosis. Keywords: epigenetics; osteoporosis; exercise; bone metabolism; DNA methylation; histone modifications; non-coding RNAs 66