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A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue[J]. PLoS Genet,9(6):1-16. RUBIN C T,MCLEOD K J,BAIN S D,1990. Functional strains and cortical bone adaptation:Epigenetic assurance of skeletal integrity [J]. J Biomech,23(1):43-54. SCHROEDER T M,NAIR A K,STAGGS R,et al.,2007. Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors[J]. BMC Genomics,8(362):1-13. SCIMECA J C, VERRON E,2017. The multiple therapeutic applications of miRNAs for bone regenerative medicine[J]. Drug Discov Today,22(7):1084-1091. SHAKIBAEI M, BUHRMANN C, MOBASHERI A, 2011. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand(RANKL)activation of NF￾kappaB signaling and inhibit osteoclastogenesis in bone-derived cells [J]. J Biol Chem,286(13):11492-11505. STANTON A M,HANDY A B,MESTON C M,2018. The effects of exercise on sexual function in women[J]. Sex Med Rev,6(4): 548-557. SUN Z,CAO X,HU Z,et al.,2015. MiR-103 inhibits osteoblast proliferation mainly through suppressing Cav1.2 expression in simulated microgravity[J]. Bone,76:121-128. SUURINIEMI M,MAHONEN A,KOVANEN V,et al.,2004. Association between exercise and pubertal BMD is modulated by estrogen receptor alpha genotype[J]. J Bone Miner Res,19(11): 1758-1765. SUWA M, NAKANO H, RADAK Z, et al.,2008. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle[J]. Metabolism,57(7):986-998. TAUNTON J,HASSIN C A,SCHREIBER S L,1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p[J]. Science,272(5260):408-411. TSENG P C,HOU S M,CHEN R J,et al.,2011. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating Runx2 gene expression via the SIRT1/FOXO3A axis 65
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