OH 6-0H R 0 R 0 →Products 0 08 Ester hydrolysis Transition state 06 R 0 R Analog (phosphonate) OH 8-0H H H-N H一】 →Products H NO NO Carbonate hydrolysis Transition state H 06 H-N H NO Box 8-3 Lehn Analog (phosphate)Box 8-3 Lehn