Fudan University Cancer Center Survival in the Circulatory System Out of many thousands of cancer cells that reach the blood circulation, only one survive to form a secondary cancer or metastasIs. Immune attack circulatory forces, apoptosis induced by loss of adhesion Bind to coagulation factors creating emboli, which are more resilient to both circulatory forces and immune attack 复旦大学上海医学院肿瘤学系复旦大学上海医学院肿瘤学系 Fudan University Cancer Center Survival in the Circulatory System • Out of many thousands of cancer cells that reach the blood circulation, only one survive to form a secondary cancer or metastasis. • Immune attack, circulatory forces , apoptosis induced by loss of adhesion • Bind to coagulation factors creating emboli, which are more resilient to both circulatory forces and immune attack