Fudan University Cancer Center Abnormal vasculature in tumor Malformed and irregular Possessing breaks in their thin lining that permit the easy access of tumor cells into the circulation dilated hyperpermeable The vasculature of normal tissue do not have these same features 复旦大学上海医学院肿瘤学系复旦大学上海医学院肿瘤学系 Fudan University Cancer Center Abnormal Vasculature in tumor • Malformed and irregular • Possessing breaks in their thin lining that permit the easy access of tumor cells into the circulation— dilated, hyperpermeable • The vasculature of normal tissue do not have these same features