Fudan University Cancer Center Intravasation Primary Tumor Intravasation: the entry of tumor cells into the circulation Tumor Cell Invasion& Migration Extravasation MMP-2 Bones Lymph Nodes. Extravasation: the MMP9 Tumor Cell Rectum exit of tumor cells Plasmin PA-R/UPA Tumor Cell from the circulation Metastasis Extracellular Matrix to host tissue Degradation intravasation Journal of carcinogenesis 2012,11: 4 复旦大学上海医学院肿瘤学系复旦大学上海医学院肿瘤学系 Fudan University Cancer Center Intravasation • Intravasation: the entry of tumor cells into the circulation • Extravasation: the exit of tumor cells from the circulation to host tissue Journal of Carcinogenesis 2012,11:4