Positive regulation mediators 1.PGE,: warm sensitive neuron cold sensitive neuron SP Effective medicine: Asprin, buprofen(Fenbid) 2. CRH(corticotrophin releasing hormone) EP (IL-1B, IL-6) CRH media, fever TNFO L-1 PGE media feverPositive regulation mediators 1.PGE2 : warm sensitive neuron cold sensitive neuron Effective medicine:Asprin,buprofen (Fenbid) 2.CRH(corticotrophin releasing hormone) EP (IL-1β, IL-6 ) CRH media fever TNFα, IL-1 α PGE2 media fever SP