Synthesis of Amines SN2 Reaction of Alkyl Halides Ammonia and other amines are good nucleophiles in SN2 reactions Alkylamines are synthesized most simply by SN2 alkylation of ammonia or an alkylamine with an alkyl halide R- SN2 NaOH Ammonia NH3 + RNH3 X RNH2 Primary RNH2+ SN2 NaOH Primary R2NH2 X R2NH Secondary Secondary R2NH+ SN2 R3NH X- NaOH R3N Tertiary Tertiary R3N 1+ SN2 RAN X- Quaternary ammonium Cengage Leaming All Pighs Pesarved SN2 Reaction of Alkyl Halides ▪ Ammonia and other amines are good nucleophiles in SN2 reactions ▪ Alkylamines are synthesized most simply by SN2 alkylation of ammonia or an alkylamine with an alkyl halide Synthesis of Amines