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The kappa and lambda loci undergo similar rearrangement. Since there are no D segments,there is a single V-->J rearrangement. In both heavy and light chain rearrangement,a number of J segments may remain between the V(D)and C segments. These are included in the RNA transcript but are spliced out during RNA processing. The final light chain mRNA contains one VJC unit. Germ-line LVvl LVK23 LVkn CK K-chain DNA VJ joining L VKl L Vk Ik JK Rearranged K-chain DNA 5☐…☐3 Kuby Figure 5-4 The kappa and lambda loci undergo similar rearrangement. Since there are no D segments, there is a single V-->J rearrangement. In both heavy and light chain rearrangement, a number of J segments may remain between the V(D) and C segments. These are included in the RNA transcript but are spliced out during RNA processing. The final light chain mRNA contains one VJC unit. Kuby Figure 5-4
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