Mechanism ofAction of(AMB This kind of antifungal agents act against sensitive fungal by combining with membrane ergosterols with subsequent aeration in permeability and loss of essential organic and inorganic cell constituents In mammalian cell membranes, the principal sterol is chloesterol(a 甾醇, AMB binds approximately times more tightly to vesicles(醇囊) containing ergosterol rather than to those containing chloesterol Side-effects The most serious are hypokalemia and distal tubular acidosis. the Nephrotoxicity has been lessened to some extent by lipid complexed formulationsMechanism of Action of (AMB) This kind of antifungal agents act against sensitive fungal by combining with membrane ergosterols with subsequent aleration in permeability and loss of essential organic and inorganic cell constituents. In mammalian cell membranes, the principal sterol is chloesterol(胆 甾醇), AMB binds approximately times more tightly to vesicles (醇囊) containing ergoesterol rather than to those containing chloesterol. Side-effects The most serious are hypokalemia and distal tubular acidosis. the Nephrotoxicity has been lessened to some extent by lipid￾complexed formulations