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Expert Opinion on Biological Therapy,2014,14(6):821-830 [24]蒋大光,王晓玲,孙玉斌国内生物黏合剂的研究近况与前景[门.中国冶金工业医学杂志,1997(4):233-234 [25]赵双琪,王克敏.多巴胺在黏合剂上的研究进展[].黏接,2015(1):41-44 [26] RYU J H, HONG S, LEE H. Bio-inspired adhesive catechol-conjugated chitosan for biomedical applications: A mini review [I Acta Biomaterialia, 2015, 27: 101-115 [27] DRURY J L, MOONEY D J. Hydrogels for tissue engineering: Scaffold design variables and applications []. Biomaterials. 2003,24(24):4337-4351 [ 28] CHEN H L, CHENG JW, RAN L X, et al. An injectable self-healing hydrogel with adhesive and antibacterial properties effectively promotes wound healing [J]. Carbohydrate Polymers, 2018, 201: 522-531 [29] CHENAULT H K, BHATIA S K, JR DM, et al. Sealing and healing of clear comeal incisions with an improved dextran aldehyde PEG amine tissue adhesive []. Current Eye Research, 2011, 36(11):997-1004 [30] QU J, ZHAO X, LIANG Y, et al. Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and D]. Biomater [31] MATSUMURA K, NAKAJIMAN, SUGAI H, et al. Self-degradation of tissue adhesive based on oxidized dextran and poly-L-lysine UJ]. Carbohydrate Polymers, 2014, 113:32-38 [32] YE M, JIANG R, ZHAO J, et al. In situ formation of adhesive hydrogels based on PL with laterally grafted catechol groups and their bonding efficacy to wet organic substrates [J] Journal of Materials Science Materials in Medicine, 2015, 26: 273 [33] YU F, CAO X D, DU J, et al. Multifunctional hydrogel with good structure integrity, self-healing, and tissue-adhesive property formed by combining Diels-Alder click reaction and acy hydrazone bond [J]. ACS Applied Materials Interfaces, 2015 7(43):24023-24031 [34] YAN S, WANG W, LI X, et al. Preparation of mussel-inspired injectable hydrogels based on dual-functionalized alginate with improved adhesive, self-healing, and mechanical properties [J] Journal of Materials Chemistry B, 2018, 6(40):6377-6390 [35] REN K, LI B, XU Q, et al. Enzymatically crosslinked hydrogels based on linear poly(ethylene glycol) polymer: Performance and mechanism [J]. Polymer Chemistry, 2017, 8(45):7017-7024 [36] LEE Y, BAE J W, OH D H, et al. In situ forming gelatin-based tissue adhesives and their phenolic content-driven properties [] Journal of Materials Chemistry B, 2013, 1(18):2407-2414 37] HOU J, LI C, GUAN Y, et al. Enzymatically crosslinked alginate hydrogels with improved adhesion properties []. Polymer Chemistry,2015,6(12):2204-2213 [38] WANG R, XU D, LIANG L, et al. Enzymatically crosslinked epsilon-poly-L-lysine hydrogels with inherent antibacterial properties for wound infection prevention [J]. RSC Advances, 2016, 6(11): 8620-8627 39] WANG T, MU X, LI H, et al. The photocrosslinkable tissue adhesive based on copolymeric dextran/HEMA []. CarbohydrateMacromolecular Rapid Communications,2018,39(18):1800272. LI Z, YUAN B, DONG X, et al. Injectable polysaccharide hybrid hydrogels as scaffolds for burn wound healing [J]. RSC Advances,2015,5(114):94248-94256. [ 13 ] LI X, DING J, ZHANG Z, et al. Kartogenin-incorporated thermogel supports stem cells for significant cartilage regeneration [J]. ACS Applied Materials & Interfaces,2016,8(8):5148-5159. [ 14 ] LIU H, CHENG Y, CHEN J, et al. Component effect of stem cell-loaded thermosensitive polypeptide hydrogels on cartilage repair [J]. Acta Biomaterialia,2018,73:103-111. [ 15 ] YAN S, ZHANG X, ZHANG K, et al. Injectable in situ forming poly(L-glutamic acid) hydrogels for cartilage tissue engineering [J]. Journal of Materials Chemistry B,2016,4(5):947-961. [ 16 ] REN K, CUI H, XU Q, et al. Injectable polypeptide hydrogels with tunable microenvironment for 3D spreading and chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells [J]. Biomacromolecules,2016,17(12):3862-3871. [ 17 ] REN K, HE C, XIAO C, et al. Injectable glycopolypeptide hydrogels as biomimetic scaffolds for cartilage tissue engineering [J]. Biomaterials,2015,51:238-249. [ 18 ] [ 19 ] ZHANG Y S, KHADEMHOSSEINI A. Advances in engineering hydrogels [J]. Science,2017,356(6337):eaaf3627. HAN L, YAN L, WANG K, et al. Tough, self-healable and tissue-adhesive hydrogel with tunable multifunctionality [J]. NPG Asia Materials,2017,9(4):e372. [ 20 ] LIU X, ZHANG Q, LI K, et al. Multipurpose and durable adhesive hydrogel assisted by adenine and uracil from ribonucleic acid [J]. Chemistry: A European Journal,2018,24(56):15119-15125. [ 21 ] KORD F P, LEE B P. Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein [J]. Journal of Polymer Science Part A: Polymer Chemistry,2017,55(1):9-33. [ 22 ] SAMUEL P, MANDELL N S G. Fibrin sealants: Surgical hemostat, sealant and adhesive [J]. Expert Opinion on Biological Therapy,2014,14(6):821-830. [ 23 ] [ 24 ] 蒋大光, 王晓玲, 孙玉斌. 国内生物黏合剂的研究近况与前景 [J]. 中国冶金工业医学杂志,1997(4):233-234. [ 25 ] 赵双琪, 王克敏. 多巴胺在黏合剂上的研究进展 [J]. 黏接,2015(1):41-44. RYU J H, HONG S, LEE H. Bio-inspired adhesive catechol-conjugated chitosan for biomedical applications: A mini review [J]. Acta Biomaterialia,2015,27:101-115. [ 26 ] DRURY J L, MOONEY D J. Hydrogels for tissue engineering: Scaffold design variables and applications [J]. Biomaterials, 2003,24(24):4337-4351. [ 27 ] CHEN H L, CHENG J W, RAN L X, et al. An injectable self-healing hydrogel with adhesive and antibacterial properties effectively promotes wound healing [J]. Carbohydrate Polymers,2018,201:522-531. [ 28 ] CHENAULT H K, BHATIA S K, JR D M, et al. Sealing and healing of clear corneal incisions with an improved dextran aldehydePEG amine tissue adhesive [J]. Current Eye Research,2011,36(11):997-1004. [ 29 ] QU J, ZHAO X, LIANG Y, et al. Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing [J]. Biomaterials,2018,183:185-199. [ 30 ] MATSUMURA K, NAKAJIMA N, SUGAI H, et al. Self-degradation of tissue adhesive based on oxidized dextran and poly-L-lysine [J]. Carbohydrate Polymers,2014,113:32-38. [ 31 ] YE M, JIANG R, ZHAO J, et al. In situ formation of adhesive hydrogels based on PL with laterally grafted catechol groups and their bonding efficacy to wet organic substrates [J]. Journal of Materials Science Materials in Medicine,2015,26:273. [ 32 ] YU F, CAO X D, DU J, et al. Multifunctional hydrogel with good structure integrity, self-healing, and tissue-adhesive property formed by combining Diels-Alder click reaction and acylhydrazone bond [J]. ACS Applied Materials & Interfaces,2015, 7(43):24023-24031. [ 33 ] YAN S, WANG W, LI X, et al. Preparation of mussel-inspired injectable hydrogels based on dual-functionalized alginate with improved adhesive, self-healing, and mechanical properties [J]. Journal of Materials Chemistry B,2018,6(40):6377-6390. [ 34 ] REN K, LI B, XU Q, et al. Enzymatically crosslinked hydrogels based on linear poly(ethylene glycol) polymer: Performance and mechanism [J]. Polymer Chemistry,2017,8(45):7017-7024. [ 35 ] LEE Y, BAE J W, OH D H, et al. In situ forming gelatin-based tissue adhesives and their phenolic content-driven properties [J]. Journal of Materials Chemistry B,2013,1(18):2407-2414. [ 36 ] HOU J, LI C, GUAN Y, et al. Enzymatically crosslinked alginate hydrogels with improved adhesion properties [J]. Polymer Chemistry,2015,6(12):2204-2213. [ 37 ] WANG R, XU D, LIANG L, et al. Enzymatically crosslinked epsilon-poly-L-lysine hydrogels with inherent antibacterial properties for wound infection prevention [J]. RSC Advances,2016,6(11):8620-8627. [ 38 ] [ 39 ] WANG T, MU X, LI H, et al. The photocrosslinkable tissue adhesive based on copolymeric dextran/HEMA [J]. Carbohydrate 136 功 能 高 分 子 学 报 第 33 卷