Factors Determining Interindividual Variations in Drug Response High/Body weight Genetic factors Sex Environmental Factors Age 白 iet/Smoking Elderly Comedications Children Interindividual Neonates Variability in Drug Response Disease Process Organ function 个 Liver,Kidney,Cardiac Concomitant DiseaseFactors Determining Interindividual Variations in Drug Response Sex High/Body weight Environmental Genetic factors Age Elderly Children Neonates Concomitant Disease Disease Process Organ function Liver, Kidney, Cardiac Environmental Factors Diet / Smoking / Comedications Interindividual Variability in Drug Response