Case report 1 Case report 2 ● 62 y.0.man hospitalized 56 y.o.man hospitalized for pneumonia with cough for hypertension ● Treated with“standard” doses of Codeine as a “Ordinary”Metoprolol (B1 adrenergic receptor inhibitor) cough suppressant 20mg bid ● Coma Morphine levels 20X Blood pressure not expected levels decreaseCase report 1 62 y.o. man hospitalized for pneumonia with cough Treated with “standard” 56 y.o. man hospitalized for hypertension “Ordinary ” Metoprolol Case report 2 Treated with “standard” doses of Codeine as a cough suppressant Coma Morphine levels 20 × expected levels “Ordinary ” Metoprolol (β1 adrenergic receptor inhibitor) 20mg bid Blood pressure not decrease