Changes in the brain The presence of Lewy bodies. Clumps of specific substances within brain cells are microscopic markers A Lewy body, pictured above, contains a mass of proteins, including synuclein, of Pd. researchers believe these and is a characteristic feature of Parkinson's disease neural tissue Lewy bodies hold an important clue to the cause of parkinson's disease Normal Alpha-synuclein is found within Lewy bodies. An important natural and widespread protein among arkinson many It's found in all Lewy bodies in Pre a clumped form that cells can't break downChanges in the Brain • The presence of Lewy bodies. Clumps of specific substances within brain cells are microscopic markers of PD. Researchers believe these Lewy bodies hold an important clue to the cause of Parkinson's disease. • Alpha-synuclein is found within Lewy bodies. An important natural and widespread protein among many. It's found in all Lewy bodies in a clumped form that cells can't break down